neuro-genetic correlations in four siblings with chronic limb ulcers and amputations resulting from hereditary sensory and autonomic neuropathy type 2

hereditary sensory and autonomic neuropathies (hsan) are clinically and genetically a heterogeneous group of disorders. there are overlapping variants of hsan regarding clinical manifestations and pathologic findings. five types of hsan have been described by dyck (1993) and there are two other types which have been introduced recently. we report four siblings that seem to suffer from symptomatic hsan ii, the progressive form of autosomal recessive sensory neuropathy, and our findings emphasize the neurogenetic correlations and clinical heterogeneity of hsan.